What does MYCL mean?
MYCL
| Acronym | Definition |
|---|---|
| MYCL | Minnesota Youth Community Learning (University of Minnesota initiative) |
| MYCL | Model Yacht Club Limburg (Netherlands) |
Is L myc an oncogene?
The L-myc gene is the third member of the myc family of proto-oncogenes. Amplification and elevated expression of the L-myc gene has been detected in a subset of small cell lung carcinoma (SCLC) cell lines.
What does N myc stand for?
N-Myc
| MYCN | |
|---|---|
| Aliases | MYCN, MODED, N-myc, NMYC, ODED, bHLHe37, v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog, MYCN proto-oncogene, bHLH transcription factor |
| External IDs | OMIM: 164840 MGI: 97357 HomoloGene: 3922 GeneCards: MYCN |
| showGene location (Human) | |
| showGene location (Mouse) |
What result does C MYC have on transcription?
In cancer, c-myc is often constitutively (persistently) expressed. This leads to the increased expression of many genes, some of which are involved in cell proliferation, contributing to the formation of cancer….Myc.
| MYC proto-oncogene, bHLH transcription factor | |
|---|---|
| Identifiers | |
| NCBI gene | 4609 |
| HGNC | 7553 |
| OMIM | 190080 |
What is oncogene and proto oncogene?
Proto-oncogenes are normal genes that help cells grow. An oncogene is any gene that causes cancer.
What is the function of Myc?
MYC gene encodes a multifunctional, nuclear phosphoprotein that controls a variety of cellular functions, including cell cycle, cell growth, apoptosis, cellular metabolism and biosynthesis, adhesion, and mitochondrial biogenesis.
What is the difference between N myc and c-myc?
c-Myc is broadly overexpressed in both blood-borne and solid tumors. N-myc is most frequently overexpressed in solid cancers of neural origin, such as neuroblastoma and glioma.
What does the Myc gene do?
What is the difference between MYC and MYCN?
Expression of MYCN is tissue specific, and is found during early developmental stages, whereas expression of MYC is more generalized (Fig. 1C). For example, expression of MYCN is highest in forebrain, kidney, and hindbrain of newborn mice, and is virtually absent in all tissues of adult mice.
What is oncogenic signaling?
Intricate networks of multiple signaling pathways that cross interact with each other, control the growth and progression of a tumor.
What is the MYCL gene?
MYCL (MYCL Proto-Oncogene, BHLH Transcription Factor) is a Protein Coding gene. Diseases associated with MYCL include Apocrine Adenosis Of Breast and Lung Cancer .
Is MYCL1 involved in the pathophysiology of gastric cancer?
MYCL1 protein expression encoded by a proto-oncogene MYCL1, a member of the MYC family, is correlated with poor prognosis in gastric cancer patients. Nevertheless, the role of MYCL1 in gastric cancer cells remains unknown.
Is there a role for Myc proteins in small cell lung cancer?
Small cell lung cancer (SCLC) is the most aggressive type of lung cancer with high mortality. One of the MYC family genes, MYC, MYCL or MYCN, is amplified in ~20% of the SCLCs; therefore, MYC proteins are potential therapeutic targets in SCLC patients.
What diseases are associated with the myelodysplastic syndrome (MYCL)?
Diseases associated with MYCL include Apocrine Adenosis Of Breast and Lung Cancer . Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and protein dimerization activity .