Is EBV associated with Burkitt lymphoma?

Is EBV associated with Burkitt lymphoma?

In particular, some cases of Burkitt lymphoma (BL) are caused by Epstein-Barr Virus (EBV), the first human tumor virus to be discovered. In the decades since the discovery of EBV, we have learned that contributions that EBV makes to the formation and maintenance of Burkitt lymphomas are complex.

Can lymphoma be caused by Epstein Barr virus?

The Epstein-Barr virus (EBV) is the virus that causes mononucleosis, also known as “mono,” and it is associated with some types of NHL. These include Burkitt lymphoma, lymphomas occurring after an organ transplant, and, rarely, other lymphomas in people who are otherwise healthy.

Which lymphoma is associated with Epstein Barr virus infection?

The Epstein–Barr virus (EBV) is linked to various B-cell lymphomas, including Burkitt lymphoma (BL), classical Hodgkin lymphoma (cHL) and diffuse large B-cell lymphoma (DLBCL) at frequencies ranging, by routine techniques, from 5 to 10% of cases in DLBCL to >95% in endemic BL.

Why does EBV cause Burkitt’s lymphoma?

Subsequently, studies have shown that EBV has the ability to immortalize B-lymphocytes by hindering apoptosis signals within the cell. The virally encoded cells, therefore, proliferate to high numbers in the body leading to malignancies. EBV can subsequently change the B-lymphocytes to lymphoblastoid cell lines.

What is Burkitt lymphoma?

Burkitt lymphoma is a type of non-Hodgkin lymphoma (NHL). NHL is a cancer of the lymphatic system. It develops when the body makes abnormal B lymphocytes. These lymphocytes are a type of white blood cell that normally help to fight infections.

How long can you live with Burkitt lymphoma?

For adults with low-risk disease, the five-year survival rate is about 71%, while high-risk aggressive lymphomas have about a 29% five-year survival rate. The survival rate decreases as the patient’s age increases.

Is Burkitt lymphoma metastatic?

Infections: Burkitt’s lymphoma, HIV infection and chemotherapy treatments which suppress the immune system can all put a person at risk for infections. Spread of the cancer (metastasis): Burkitt’s lymphoma can spread to the abdominal organs, bone marrow, brain and spinal cord.

How aggressive is Burkitt lymphoma?

Burkitt lymphoma is a very fast-growing (aggressive) type of NHL. It tends to occur in organs or tissues other than the lymph nodes (called extranodal sites). It often spreads to the brain or spinal cord (called the central nervous system, or CNS).

What are the symptoms of Burkitt’s lymphoma?

Other symptoms of Burkitt’s lymphoma vary according to type. The symptoms of sporadic Burkitt’s lymphoma include: The symptoms of endemic Burkitt’s lymphoma include swelling and distortion of facial bones and a rapid growth of lymph nodes.

Does EBV play a role in the pathophysiology of Burkitt’s lymphoma?

Thus, in effect, EBV collaborates with the translocations associated with Burkitt’s lymphoma in causing c-myc deregulation. This collaboration is independent of the breakpoint location.

What is sporadic Burkitt’s lymphoma?

Sporadic Burkitt’s lymphoma (also called non-African Burkitt’s lyphoma) is a distinct form of the disease, though cancer cells will often appear similar to endemic Burkitt’s. It is also related to Epstein-Barr virus and tends to affect the ileo-cecal region more frequently than the jaw.

What are the risk factors for Burkitt’s lymphoma?

Risk factors vary according to geographic location. Research suggests that Burkitt’s lymphoma is the most common childhood cancer in regions where there is a high incidence of malaria, like Africa. Elsewhere, the greatest risk factor is HIV. What are the types of Burkitt’s lymphoma?