Is SOD2 a protein?
Superoxide dismutase 2, mitochondrial (SOD2), also known as manganese-dependent superoxide dismutase (MnSOD), is an enzyme which in humans is encoded by the SOD2 gene on chromosome 6. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit.
What does sod3 gene do?
This gene encodes a member of the superoxide dismutase (SOD) protein family. SODs are antioxidant enzymes that catalyze the dismutation of two superoxide radicals into hydrogen peroxide and oxygen. The product of this gene is thought to protect the brain, lungs, and other tissues from oxidative stress.
What is the function of SOD2?
Eukaryotic systems have evolved defenses against such damaging moieties, the chief member of which is superoxide dismutase (SOD2), an enzyme that efficiently converts superoxide to the less reactive hydrogen peroxide (H2O2), which can freely diffuse cross the mitochondrial membrane.
Where is SOD2 found?
Mammalian SOD2 is exclusively located in mitochondria and not present in peroxisomes. Histochem Cell Biol.
What is the role of superoxide dismutase?
Superoxide dismutases (SODs) constitute a very important antioxidant defense against oxidative stress in the body. The enzyme acts as a good therapeutic agent against reactive oxygen species-mediated diseases.
Where is SOD3 located?
As a secreted protein, SOD3 is localized primarily within the extracellular matrix and at cell surfaces, through interactions with a heparin/matrix-binding domain within the enzyme.
What is the SOD2 gene?
SOD2 (Superoxide Dismutase 2) is a Protein Coding gene. Diseases associated with SOD2 include Microvascular Complications Of Diabetes 6 and Gastric Cancer . Among its related pathways are DNA Damage Response (only ATM dependent) and Detoxification of Reactive Oxygen Species .
What is SOD2 and why is it so important?
SOD2 plays a key role by processing superoxide into less harmful products which can then be processed or cleared outside of the mitochondria, allowing continued mitochondrial function and preventing damage. There is one SNP in the SOD2 gene which is associated with poor health outcomes, rs4880 sometimes called T47C or A16V.
Does glutathione interact with SOD2?
There is no direct interaction with SOD2; however, in those carrying the risk ‘T’ allele of T47C which is associated with reduced SOD2 antioxidant capacity, glutathione may supplement for this reduced activity. Discuss this information with your doctor before taking any course of action.
Does manganese increase SOD2?
Supplementation with manganese has been shown to increase SOD2 activity in two lab models, but it is unclear if there will be a direct benefit to humans 11, 12. Vitamin C is one of the most potent antioxidants, which can protect against oxidative stress induced by free radicals 13.