What are side effects of sirolimus?
Sirolimus may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- stomach pain.
- headache.
- constipation.
- diarrhea.
- nausea.
- joint pain.
What is the drug Rapamune used for?
This medication belongs to a class of drugs known as immunosuppressants. It works by weakening your body’s defense system (immune system) to help your body accept the new organ as if it were your own. Sirolimus may also be used to treat a certain lung disease (lymphangioleiomyomatosis-LAM).
Is sirolimus hard on kidneys?
Sirolimus is a very strong medicine. It can cause side effects that can be very serious, such as kidney problems. It may also reduce the body’s ability to fight infections.
What is sirolimus toxicity?
Conclusions Severe adverse effects of sirolimus include fever, anemia, and capillary leak syndrome. These symptoms may be the result of drug-induced apoptosis of lesional leukocytes, especially activated T lymphocytes, and possibly release of inflammatory mediators.
How safe is sirolimus?
Sirolimus was proven effective and safe. Vascular anomalies are a spectrum of rare diseases classified into vascular tumors and malformations. An updated classification system was adopted at the International Society for the Study of Vascular Anomalies (ISSVA) in April 2014 .
Can Rapamune cause diabetes?
Diabetes: Sirolimus may cause a loss of control of diabetes by increasing blood glucose (sugar). It may also cause the onset of diabetes for people who are at risk.
Does Rapamune cause stomach problems?
Adverse reactions occurring at a frequency of ≥20% in the Rapamune treatment group and greater than placebo include stomatitis, diarrhea, abdominal pain, nausea, nasopharyngitis, acne, chest pain, peripheral edema, upper respiratory tract infection, headache, dizziness, myalgia, and hypercholesterolemia.
Can you overdose on sirolimus?
Even large overdoses appeared to be well-tolerated, however children might be at greater risk of developing complications. Further study of sirolimus overdose is needed.
Does sirolimus cause swelling?
However, seek immediate medical attention if you notice any of the following symptoms of a serious allergic reaction: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. Sirolimus can commonly cause a mild rash that is usually not serious.
Is sirolimus better than tacrolimus?
In conclusion, our meta-analysis of randomized trials and cost evaluation model have shown renal transplant recipients maintained on tacrolimus have better outcomes than patients maintained on sirolimus. And tacrolimus may be more cost-effective than sirolimus for the primary prevention of AR in renal transplant.
Does sirolimus cause liver damage?
The liver injury associated with sirolimus therapy is usually mild and transient, resolving on its own or with dose modification or discontinuation. Sirolimus has not been linked to cases of acute liver failure or vanishing bile duct syndrome.
Does sirolimus cause weight gain?
Treatment with sirolimus is associated with less weight gain after kidney transplantation. Transplantation.
Is priapism a side effect of Prozac?
This is a rare side effects of medications that work on serotonin, like Prozac, but can occur if you’re on more than one drug that affects serotonin levels—which can overload your system.
Is nausea a side effect of Pradaxa?
What is the most common side effect of Pradaxa? Common side effects may include: stomach pain or discomfort; indigestion; or. nausea, diarrhea.
Is rebound effect a side effect of Allegra?
Rebound effect is found among people who take Allegra, especially for people who are female, 40-49 old, have been taking the drug for 10+ years. The phase IV clinical study analyzes which people take Allegra and have Rebound effect. It is created by eHealthMe based on reports of 60,868 people who have side effects when taking Allegra from the FDA, and is updated regularly.