What cardiotoxic means?
Cardiotoxicity is a condition when there is damage to the heart muscle. As a result of cardiotoxicity, your heart may not be able to pump blood throughout your body as well. This may be due to chemotherapy drugs, or other medications you may be taking to control your disease.
What are the symptoms of cardiotoxicity?
Symptoms of Cardiotoxicity
- Shortness of breath.
- Chest Pain.
- Heart palpitations.
- Fluid retention in the legs.
- Distention of the stomach.
- Dizziness.
What drugs are cardiotoxic?
Chemotherapy and other anti-cancer drugs are designed to combat cancer….The most common chemotherapy drugs related to cardio-toxicity include:
- 5-fluorouracil (Adrucil)
- Paclitaxel (Taxol)
- Anthracyclines (a class of drugs)
- Targeted therapies: such as monoclonal antibodies and tyrosine kinase inhibitors.
- Some Leukemia drugs.
How is cardiotoxicity treated?
The most common medications used for cardiotoxicity treatment include: Beta-blockers, which slow down a patient’s heart rate, lower a patient’s blood pressure and strengthen the heart muscle can reduce palpitations and arrhythmias, hypertension and heart failure.
How is cardiotoxicity diagnosed?
Standard current methods for detection of cardiotoxicity primarily involve serial measurement of the left ventricular ejection fraction (LVEF), a parameter that when reduced is a late manifestation in the cardiotoxic paradigm and when the possibility for reversibility declines.
Is digoxin a cardiotonic?
The active components of the foxglove (Digitalis purpurea and Digitalis lanata) are classified as cardiac glycosides or cardiotonic steroids and include the well-known digitalis leaf, digitoxin, and digoxin; ouabain is a rapid-acting glycoside usually obtained from Strophanthus gratus.
Is cardiotoxicity reversible?
With the exception of anthracyclines, cardiotoxicity from most targeting agents is reversible. Concomitant use of cardiotoxic drugs should be avoided, and early detection of asymptomatic cardiac dysfunction is important.
What is the most toxic chemotherapy regimen?
Direct pairwise meta-analysis results also revealed that the gemcitabine + carboplatin chemotherapy regimen was the most toxic regimen in hematologic for AOC patients among 8 chemotherapy regimens. Specifically, anemia, febrile neutropenia, and thrombocytopenia had larger OR and 95%CI.
Is paclitaxel cardiotoxic?
Paclitaxel has cardiotoxic effects. Careful monitoring of cardiac function during and after paclitaxel infusion is required in patients with high-risk features.
Can you recover from cardiotoxicity?
The median time elapsed between the end of chemotherapy and cardiotoxicity development was 3.5 (quartile 1 to quartile 3, 3–6) months. In 98% of cases (n=221), cardiotoxicity occurred within the first year. Twenty-five (11%) patients had full recovery, and 160 (71%) patients had partial recovery.
Which chemotherapy causes cardiomyopathy?
Causes of Cardiomyopathy in Cancer Patients They include doxorubicin (Adriamycin® and Rubex®), daunorubicin (Cerubidine®), epirubicin (Ellence®), and idarubicin (Idamycin®). You’re more likely to get cardiomyopathy from these medications if you get high doses of them.
What is cardiotoxicity?
Cardiotoxicity. Cardiotoxicity is the occurrence of heart electrophysiology dysfunction or muscle damage. The heart becomes weaker and is not as efficient in pumping and therefore circulating blood. Cardiotoxicity may be caused by chemotherapy treatment, complications from anorexia nervosa, adverse effects of heavy metals intake,…
How is cardiotoxicity diagnosed in subconical heart disease?
One of the ways to detect cardiotoxicity at early stages when there is a subconical dysfunction is by measuring changes in regional function of the heart using strain.
What is chemotherapy-induced cardiotoxicity?
Cardiotoxicity can develop during cancer treatment – or – can occur within days or months or years after cancer treatment, once patients are cancer-free. Heart damage caused by chemotherapy-induced cardiotoxicity can reduce quality of life and increase the risk of death from cardiac-related causes.
What is the prognosis of cardiotoxicity after cancer treatment?
The type and degree of cardiotoxicity patients experience after cancer therapy depends primarily on the agent administered, dose, duration and frequency of treatment [191,194].