What does EBV VCA IgG positive mean?
The presence of VCA IgG antibodies indicates that an EBV infection has occurred at some time recently or in the past. The presence of VCA IgM antibodies and the absence of antibodies to EBNA mean that the infection has occurred recently. The presence of antibodies to EBNA means that the infection occurred in the past.
What is EBV EBNA IgG?
Aid in the diagnosis of EBV infections (infectious mononucleosis). EBV nuclear antigen (EBNA) IgG antibodies do not appear during the acute phase of infection but appear around 2-4 months after initial clinical presentation and typically persist for life.
What does it mean if your EBV is high?
Some types of EBV antibodies are present in higher numbers during an active infection. Other EBV antibodies mean that you had an infection in the past. Depending on the type of antibodies your test shows, your healthcare provider can find out more about what is causing your illness.
What does it mean if you have Epstein-Barr antibodies?
If you have antibodies to both VCA and EBNA, it means you’ve had an infection in the past. It could have been months or years ago. Most adults have these antibodies, because over 90% of adults have been infected with EBV at some point.
What is a normal EBV VCA IgG level?
Optimal Result: 0 – 17.9 U/mL. EBV-VCA, IgG is an antibody (protein) that is produced by the body in an immune response to an Epstein-Barr virus antigen.
Will you always test positive for Epstein-Barr?
Since approximately 90% of us have EBV, testing positive isn’t significant unless you have EBV-like symptoms that can’t be explained by another cause. Your medical provider will sort that out with you. Click here to read what the Centers for Disease Control and Prevention says about EBV.
What is anti EBNA?
Anti-EBV (EBNA-1) IgG is an ELISA-based, automated, in-vitro test system for the quantitative determination of IgG antibodies against Epstein-Barr virus nuclear antigen 1 (EBNA-1) in human serum or plasma. Epstein-Barr virus (EBV) is the cause of infectious mononucleosis (glandular fever, kissing disease).
What is a normal EBV-VCA IgM level?
Optimal Result: 0 – 36 U/mL. EBV-VCA, IgM is an antibody (protein) that is produced by the body in an immune response to an Epstein-Barr virus antigen.
Which of the following cancers is associated with Epstein-Barr virus?
EBV infection increases a person’s risk of getting nasopharyngeal cancer (cancer of the area in the back of the nose) and certain types of fast-growing lymphomas such as Burkitt lymphoma. It may also be linked to Hodgkin lymphoma and some cases of stomach cancer.
Can VCA IgG be present without EBNA-1 IgG?
However, serological findings may sometimes be difficult to interpret as VCA IgG can be present without VCA IgM or EBNA-1 IgG in cases of acute or past infection, or all the three parameters may be detected simultaneously in the case of recent infection or during the course of reactivation.
Can EBNA IgG be used to identify reactivation?
It has been suggested that EBNA IgM may be useful in identifying reactivation[114]. The combination of negative EBNA IgG and positive EBNA IgM, in addition to a high degree of avidity for VCA IgG within 3 mo of an acute infection, should reliably indicate reactivation rather than primary EBV infection[67].
Is VCA IgG a marker of reactivation?
The combination of negative EBNA IgG and positive EBNA IgM, in addition to a high degree of avidity for VCA IgG within 3 mo of an acute infection, should reliably indicate reactivation rather than primary EBV infection[67]. It has also been suggested that VCA IgA may be a marker of reactivation.
What is the significance of EA (D) IgG in EBV infection?
The presence of EA (D) IgG may help indicate a past infection as approximately 20%-30% of healthy subjects with a history of EBV infection have EA (D) IgG[2,23,25], but nothing can be said in the case of negativity. However, immunoblotting for IgG can solve the problem as it can confirm the real presence of EBNA-1 IgG.