What is the PERK pathway?

What is the PERK pathway?

The PERK/ATF4 signaling is now accepted as a typical pathway mediating ER stress-induced autophagy. It is believed that activated FoxO facilitates the expression of Bnip3, which displaces the autophagic effecter Beclin1 from Bcl-XL complexes to induce autophagy.

Is Perk a kinase?

Eukaryotic translation initiation factor 2-alpha kinase 3, also known as protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK), is an enzyme that in humans is encoded by the EIF2AK3 gene.

What is phospho Erk?

Phospho-ERK is a biomarker of response to a synthetic lethal drug combination of sorafenib and MEK inhibition in liver cancer. J Hepatol.

Is CHOP a protein?

CHOP belongs to the family of CCAAT/enhancer binding proteins (C/EBPs) and is involved in the regulation of genes that encode proteins involved in proliferation, differentiation and expression, and energy metabolism. CHOP is a 29 kD protein with 169 (human) or 168 (rodents) amino acid residues.

What happens if the endoplasmic reticulum stops working?

The ER is responsible for processing proteins. Most of the dry weight (meaning, non-water weight) of the cell is proteins. Without the ER, many of them either wouldn’t work or wouldn’t get where they needed to be and the cell would die.

What is the function of EIF2AK3?

PKR-like ER kinase (PERK, EIF2AK3) is an elF2alpha kinase that inhibits protein translation. PERK is a type one endoplasmic reticulum (ER) membrane protein which is involved in both the integrated stress response (ISR) and unfolded protein response (UPR).

What are the best pERK antibodies for EIF2AK3?

Compare Top PERK Proteins Santa Cruz Biotechnology (SCBT) Antibodies for EIF2AK3 PERK (B-5) PERK (B-5): m-IgGκ BP-HRP Bundle PERK (B-5): m-IgG Fc BP-HRP Bundle Search Santa Cruz Biotechnology (SCBT) for EIF2AK3 siRNA/shRNA

How many genes share pathways with EIF2AK3?

5 PERK regulates gene expression PERK regulates gene expression .90 Genes that share pathways with EIF2AK3: view Pathways by source for EIF2AK3 Gene

What causes EIF2AK3 syndrome?

This syndrome is caused by recessive loss of function mutations in the EIF2AK3 gene. The EIF2AK3 gene encodes a protein called pancreatic PKR-like endoplasmic reticulum kinase (PERK), which plays a key role in detecting and initiating the cellular response to endoplasmic reticulum stress, insulin secretion and trafficking.